Motif ID: NFY{A,B,C}.p2

Z-value: 3.391


Transcription factors associated with NFY{A,B,C}.p2:

Gene SymbolEntrez IDGene Name
Nfya 18044 nuclear transcription factor-Y alpha
Nfyb 18045 nuclear transcription factor-Y beta
Nfyc 18046 nuclear transcription factor-Y gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfyachr17_-_485489730.451.8e-10Click!
Nfybchr10_-_822267740.367.1e-07Click!
Nfycchr4_-_1204981980.249.7e-04Click!


Activity profile for motif NFY{A,B,C}.p2.

activity profile for motif NFY{A,B,C}.p2


Sorted Z-values histogram for motif NFY{A,B,C}.p2

Sorted Z-values for motif NFY{A,B,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFY{A,B,C}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_98885428 110.825 NM_011623
Top2a
topoisomerase (DNA) II alpha
chr6_+_124780226 74.686 Cdca3
cell division cycle associated 3
chr6_+_124780193 73.374 NM_013538
Cdca3
cell division cycle associated 3
chr13_+_23666249 62.675 NM_178188
Hist1h2ad
Hist1h2ai
histone cluster 1, H2ad
histone cluster 1, H2ai
chr14_-_68333666 55.527 NM_001110162
Cdca2
cell division cycle associated 2
chr13_-_22127419 53.418 NM_175659
Hist1h2ah
histone cluster 1, H2ah
chr9_-_70269246 50.099 Ccnb2
cyclin B2
chr14_+_47380287 46.918 Cdkn3
cyclin-dependent kinase inhibitor 3
chr10_-_68815606 46.171 NM_007659
Cdk1
cyclin-dependent kinase 1
chr13_-_21879086 43.650 NM_178184
Hist1h2an
histone cluster 1, H2an
chr11_+_71855939 43.211 NM_144526
Fam64a
family with sequence similarity 64, member A
chr2_-_172195998 42.893 NM_011497
Aurka
aurora kinase A
chr16_-_17125198 41.031 NM_183287
2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr8_+_59990639 39.887 NM_008252
Hmgb2
high mobility group box 2
chr14_+_47380215 39.493 NM_028222
Cdkn3
cyclin-dependent kinase inhibitor 3
chr13_+_51740600 37.467 NM_025415
Cks2
CDC28 protein kinase regulatory subunit 2
chr9_+_83728331 37.432 Ttk
Ttk protein kinase
chr13_+_51740804 37.266 Cks2
CDC28 protein kinase regulatory subunit 2
chr17_+_56443710 37.106 NM_001111078
NM_001111080
Uhrf1

ubiquitin-like, containing PHD and RING finger domains, 1

chr17_+_56443766 36.563 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr9_+_83728295 36.319 NM_001110265
NM_009445
Ttk

Ttk protein kinase

chr3_-_89222140 35.859 NM_016904
Cks1b
CDC28 protein kinase 1b
chr11_-_97049185 35.317 NM_008379
Kpnb1
karyopherin (importin) beta 1
chr8_+_86479405 34.785 NM_024184
Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr11_-_97049143 34.392 Kpnb1
karyopherin (importin) beta 1
chr3_-_27052733 34.386 NM_001177625
NM_007900
Ect2

ect2 oncogene

chr14_-_68333897 33.475 NM_175384
Cdca2
cell division cycle associated 2
chr11_+_68859125 33.104 NM_011496
Aurkb
aurora kinase B
chr11_-_102786433 32.753 NM_197959
Kif18b
kinesin family member 18B
chr1_+_136859153 32.672 NM_026024
Ube2t
ubiquitin-conjugating enzyme E2T (putative)
chr1_+_136859183 32.496 Ube2t
ubiquitin-conjugating enzyme E2T (putative)
chr11_-_102786403 32.048 Kif18b
kinesin family member 18B
chr1_+_193645351 32.036 NM_010892
Nek2
NIMA (never in mitosis gene a)-related expressed kinase 2
chr18_-_33373428 31.761 NM_133774
Stard4
StAR-related lipid transfer (START) domain containing 4
chr4_+_132324212 30.303 NM_011284
Rpa2
replication protein A2
chr11_-_78364173 29.824 NM_133706
Tmem97
transmembrane protein 97
chr1_+_141351340 29.740 NM_009791
Aspm
asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr3_-_27052794 29.523 NM_001177626
Ect2
ect2 oncogene
chr11_-_86922163 29.345 NM_175563
Prr11
proline rich 11
chr6_-_125141525 28.985 NM_146171
Ncapd2
non-SMC condensin I complex, subunit D2
chr13_+_105019053 28.002 Cenpk
centromere protein K
chr13_+_105019025 27.259 NM_181061
Cenpk
centromere protein K
chr15_-_82074765 26.920 NM_001080158
Cenpm
centromere protein M
chr5_+_30969259 26.733 NM_007681
Cenpa
centromere protein A
chr9_-_106794266 26.275 NM_029103
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr2_+_164595447 26.137 Ube2c
ubiquitin-conjugating enzyme E2C
chr2_+_164595389 26.132 Ube2c
ubiquitin-conjugating enzyme E2C
chr2_+_164595415 26.059 NM_026785
Ube2c
ubiquitin-conjugating enzyme E2C
chr13_-_23775827 25.693 NM_178189
Hist1h2ac
histone cluster 1, H2ac
chr4_-_118109775 25.445 NM_023223
Cdc20
cell division cycle 20 homolog (S. cerevisiae)
chr4_+_114672849 25.415 Stil
Scl/Tal1 interrupting locus
chr7_+_4691716 25.289 NM_001115018
NM_146177
Suv420h2

suppressor of variegation 4-20 homolog 2 (Drosophila)

chr4_+_46502141 24.834 NM_053179
Nans
N-acetylneuraminic acid synthase (sialic acid synthase)
chr9_-_21564742 24.693 Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr10_+_79317316 24.647 NM_001077363
NM_008956
Ptbp1

polypyrimidine tract binding protein 1

chr16_-_15637390 24.056 NM_008565
Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr9_-_70269326 23.813 NM_007630
Ccnb2
cyclin B2
chr13_+_109106530 23.590 NM_178683
Depdc1b
DEP domain containing 1B
chr1_-_191511950 23.403 NM_001081363
Cenpf
centromere protein F
chr13_-_21845695 23.240 NM_178183
Hist1h2ak
histone cluster 1, H2ak
chrX_+_68809128 23.041 Hmgb3
high mobility group box 3
chr11_-_40546863 23.039 NM_013552
Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr13_-_101556356 22.999 NM_172301
Ccnb1
cyclin B1
chr10_+_79317396 22.979 Ptbp1
polypyrimidine tract binding protein 1
chr11_+_86922732 22.897 NM_025377
Fam33a
family with sequence similarity 33, member A
chr9_-_106794234 22.619 Manf
mesencephalic astrocyte-derived neurotrophic factor
chr15_-_78893275 22.478 NM_144849
Ankrd54
ankyrin repeat domain 54
chrX_+_68809163 22.469 NM_008253
Hmgb3
high mobility group box 3
chr4_+_114672722 22.163 NM_009185
Stil
Scl/Tal1 interrupting locus
chr11_+_23156022 22.155 NM_001035226
NM_134014
Xpo1

exportin 1, CRM1 homolog (yeast)

chr10_-_128258639 21.969 NM_024180
Ormdl2
ORM1-like 2 (S. cerevisiae)
chr3_-_36470904 21.905 NM_009828
Ccna2
cyclin A2
chr2_+_119444033 21.859 NM_001042652
NM_133851
Nusap1

nucleolar and spindle associated protein 1

chrX_+_68809092 21.534 Hmgb3
high mobility group box 3
chrX_+_68809103 21.471 Hmgb3
high mobility group box 3
chr17_-_35653683 21.459 NM_001163763
NM_001163764
NM_025674
Tcf19


transcription factor 19


chr13_+_21902235 21.248 NM_178185
NM_001177544
Hist1h2ah
Hist1h2ap
Hist1h2ai
Hist1h2ao
histone cluster 1, H2ah
histone cluster 1, H2ap
histone cluster 1, H2ai
histone cluster 1, H2ao
chr3_-_36470845 21.169 Ccna2
cyclin A2
chr11_-_97048933 20.921 Kpnb1
karyopherin (importin) beta 1
chr17_-_35137278 20.757 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr17_-_35137291 20.574 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr9_-_106794158 20.447 Manf
mesencephalic astrocyte-derived neurotrophic factor
chr11_+_116295406 20.439 NM_176902
Fam100b
family with sequence similarity 100, member B
chr11_-_120504978 20.375 NM_144795
Pycr1
pyrroline-5-carboxylate reductase 1
chr13_-_23854226 20.114 NM_013550
Hist1h3a
histone cluster 1, H3a
chr7_+_129302998 20.106 Plk1
polo-like kinase 1 (Drosophila)
chr3_-_36470882 20.042 Ccna2
cyclin A2
chr7_-_20300724 19.988 NM_001109748
NM_016871
Tomm40

translocase of outer mitochondrial membrane 40 homolog (yeast)

chr8_-_23296255 19.769 NM_001004140
Ckap2
cytoskeleton associated protein 2
chr7_+_129303029 19.511 Plk1
polo-like kinase 1 (Drosophila)
chr3_+_32607582 19.269 Actl6a
actin-like 6A
chr7_-_52689833 19.204 NM_011304
Ruvbl2
RuvB-like protein 2
chr9_+_65738150 19.194 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr18_+_34784589 19.073 NM_009004
NM_001166406
Kif20a

kinesin family member 20A

chr7_+_129302950 18.983 NM_011121
Plk1
polo-like kinase 1 (Drosophila)
chr15_+_9001154 18.802 1110020G09Rik
RIKEN cDNA 1110020G09 gene
chr15_+_80541675 18.749 NM_144812
Tnrc6b
trinucleotide repeat containing 6b
chr9_-_21564723 18.672 NM_026282
Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr3_+_96361879 18.644 NM_001009935
NM_023719
Txnip

thioredoxin interacting protein

chr15_-_99481964 18.135 NM_012025
Racgap1
Rac GTPase-activating protein 1
chr18_+_76401531 17.734 NM_010754
Smad2
MAD homolog 2 (Drosophila)
chr13_-_23837389 17.672 NM_175653
Hist1h3c
histone cluster 1, H3c
chr9_+_44142772 17.307 NM_010436
H2afx
H2A histone family, member X
chr5_-_139936486 17.254 NM_028469
3110082I17Rik
RIKEN cDNA 3110082I17 gene
chr15_-_82075137 17.130 NM_025639
NM_178269
Cenpm

centromere protein M

chr17_+_56442759 17.067 NM_001111079
NM_010931
Uhrf1

ubiquitin-like, containing PHD and RING finger domains, 1

chr2_+_30247921 17.009 NM_020329
Dolpp1
dolichyl pyrophosphate phosphatase 1
chr2_+_25227840 16.993 NM_001081085
2010317E24Rik
RIKEN cDNA 2010317E24 gene
chr5_-_139936448 16.971 3110082I17Rik
RIKEN cDNA 3110082I17 gene
chr11_-_95936914 16.744 NM_001161419
NM_007506
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr19_+_37450854 16.700 NM_010615
Kif11
kinesin family member 11
chr2_+_119444452 16.589 Nusap1
nucleolar and spindle associated protein 1
chr19_+_29175864 16.442 NM_021525
Rcl1
RNA terminal phosphate cyclase-like 1
chr6_+_124613114 16.369 NM_145130
Lpcat3
lysophosphatidylcholine acyltransferase 3
chr16_-_22439642 16.342 NM_023794
Etv5
ets variant gene 5
chr14_-_66452720 16.332 NM_028039
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr11_+_98769464 16.329 NM_011799
Cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr15_-_38230397 16.241 NM_013692
Klf10
Kruppel-like factor 10
chr9_+_65738168 16.162 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr11_-_96777696 16.132 NM_030248
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr7_-_134185894 16.117 Kif22
kinesin family member 22
chr5_+_34001199 16.113 Tacc3
transforming, acidic coiled-coil containing protein 3
chr18_-_34911152 15.980 NM_009860
Cdc25c
cell division cycle 25 homolog C (S. pombe)
chr7_-_134185928 15.963 NM_145588
Kif22
kinesin family member 22
chr4_-_124614072 15.868 NM_026560
Cdca8
cell division cycle associated 8
chr11_+_40547143 15.807 NM_026023
Nudcd2
NudC domain containing 2
chr10_-_79862210 15.780 NM_013595
Mbd3
methyl-CpG binding domain protein 3
chr4_+_132686434 15.608 NM_153423
Wasf2
WAS protein family, member 2
chr2_+_34627729 15.517 Hspa5
heat shock protein 5
chr11_+_98769122 15.443 Cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr14_-_48037815 15.244 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr2_-_132078887 15.164 NM_011045
Pcna
proliferating cell nuclear antigen
chr15_+_98905403 14.984 NM_001162506
NM_030159
Troap

trophinin associated protein

chr11_-_6344354 14.961 H2afv
H2A histone family, member V
chr6_-_47544925 14.956 NM_001146689
NM_007971
Ezh2

enhancer of zeste homolog 2 (Drosophila)

chr11_-_68787314 14.757 NM_001101644
NM_021329
Gm4535
Rangrf
predicted gene 4535
RAN guanine nucleotide release factor
chr15_+_102126735 14.656 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr7_-_128125714 14.612 NM_007672
Cdr2
cerebellar degeneration-related 2
chr14_+_68334154 14.549 NM_001111028
NM_134073
Kctd9

potassium channel tetramerisation domain containing 9

chr2_-_126959605 14.500 NM_144818
Ncaph
non-SMC condensin I complex, subunit H
chr5_+_34000745 14.416 NM_001040435
Tacc3
transforming, acidic coiled-coil containing protein 3
chr3_-_88905775 14.351 NM_134469
Fdps
farnesyl diphosphate synthetase
chr15_+_102126686 14.347 NM_001014976
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr11_-_60230506 14.246 NM_145427
Atpaf2
ATP synthase mitochondrial F1 complex assembly factor 2
chr10_-_128142007 14.234 NM_016756
NM_183417
Cdk2

cyclin-dependent kinase 2

chr14_-_48037874 14.154 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr5_+_110715337 14.124 NM_011132
Pole
polymerase (DNA directed), epsilon
chr18_+_34784277 14.045 NM_001166407
Kif20a
kinesin family member 20A
chr3_+_159158396 13.929 NM_001172092
NM_001172093
NM_029523
Depdc1a


DEP domain containing 1a


chr2_+_34627607 13.846 NM_001163434
NM_022310
Hspa5

heat shock protein 5

chr1_+_133424461 13.833 Fam72a
family with sequence similarity 72, member A
chr13_+_23627286 13.816 NM_145073
Hist1h3g
histone cluster 1, H3g
chr16_+_14163356 13.804 NM_001114085
NM_023317
Nde1

nuclear distribution gene E homolog 1 (A nidulans)

chr11_-_60624733 13.616 NM_009171
Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr3_-_157587998 13.615 NM_145953
Cth
cystathionase (cystathionine gamma-lyase)
chr17_-_25097542 13.606 NM_198937
Hn1l
hematological and neurological expressed 1-like
chr7_-_56136405 13.579 NM_001013368
E2f8
E2F transcription factor 8
chr6_+_17015148 13.550 NM_207176
Tes
testis derived transcript
chr2_+_34627836 13.541 Hspa5
heat shock protein 5
chr2_-_127657532 13.536 NM_001113179
NM_009772
Bub1

budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)

chr4_-_147242501 13.499 Miip
migration and invasion inhibitory protein
chr17_-_34027575 13.439 NM_001195298
Kifc1
kinesin family member C1
chr2_+_152673699 13.411 NM_001141975
NM_001141976
NM_001141977
NM_001141978
NM_028109
Tpx2




TPX2, microtubule-associated protein homolog (Xenopus laevis)




chr4_+_11118500 13.296 NM_001037134
Ccne2
cyclin E2
chr16_+_14163414 13.286 Nde1
nuclear distribution gene E homolog 1 (A nidulans)
chr9_+_65738129 13.152 NM_026515
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr2_-_143836838 13.140 NM_024281
NM_133626
Rrbp1

ribosome binding protein 1

chr5_+_111269020 13.138 NM_016681
Chek2
CHK2 checkpoint homolog (S. pombe)
chr17_-_34027488 13.111 Kifc1
kinesin family member C1
chr1_-_93309713 13.101 NM_019479
Hes6
hairy and enhancer of split 6 (Drosophila)
chr2_+_166731527 13.057 NM_023565
Cse1l
chromosome segregation 1-like (S. cerevisiae)
chrX_+_20194884 13.044 NM_001167776
NM_145627
Rbm10

RNA binding motif protein 10

chr14_+_99445595 12.839 NM_175265
6720463M24Rik
RIKEN cDNA 6720463M24 gene
chr4_+_11118855 12.820 NM_009830
Ccne2
cyclin E2
chr4_+_126698629 12.812 Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr7_-_56136367 12.718 E2f8
E2F transcription factor 8
chr13_+_105019467 12.675 NM_021790
Cenpk
centromere protein K
chr14_-_68333397 12.572 Cdca2
cell division cycle associated 2
chr6_+_17015159 12.549 Tes
testis derived transcript
chr4_-_147242827 12.528 NM_001025365
Miip
migration and invasion inhibitory protein
chr5_-_138613028 12.495 NM_008568
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr16_-_18811669 12.448 NM_001161623
Cdc45
cell division cycle 45 homolog (S. cerevisiae)
chrX_+_72341192 12.210 NM_001030307
Dkc1
dyskeratosis congenita 1, dyskerin homolog (human)
chr17_-_24388262 12.203 NM_007634
Ccnf
cyclin F
chr13_+_75844906 12.178 NM_138953
Ell2
elongation factor RNA polymerase II 2
chr9_-_111174074 12.127 NM_026810
Mlh1
mutL homolog 1 (E. coli)
chr10_+_87609768 12.124 NM_028334
Nup37
nucleoporin 37
chr16_-_50432421 12.074 NM_027444
Bbx
bobby sox homolog (Drosophila)
chr11_+_55283201 12.067 NM_013716
G3bp1
Ras-GTPase-activating protein SH3-domain binding protein 1
chr11_-_120685860 12.035 NM_007988
Fasn
fatty acid synthase
chr17_-_53828596 12.017 NM_028232
Sgol1
shugoshin-like 1 (S. pombe)
chr7_-_52715059 12.015 NM_010240
Gm15590
Ftl1
Ftl2
ferritin light chain 1 pseudogene
ferritin light chain 1
ferritin light chain 2
chr6_-_6167113 12.004 NM_001177572
NM_015829
Slc25a13

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13

chr9_-_111174027 11.980 Mlh1
mutL homolog 1 (E. coli)
chr17_-_34027547 11.948 Kifc1
kinesin family member C1
chr10_+_87609736 11.945 NM_027191
Nup37
nucleoporin 37
chr6_-_6167086 11.945 Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr2_-_129122892 11.898 NM_181589
Ckap2l
cytoskeleton associated protein 2-like
chrX_-_99352341 11.897 NM_146235
Ercc6l
excision repair cross-complementing rodent repair deficiency complementation group 6 - like
chr19_+_4097344 11.853 NM_026373
Cdk2ap2
CDK2-associated protein 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.71 3.63e-47 GO:0044260 cellular macromolecule metabolic process
1.56 3.39e-46 GO:0044237 cellular metabolic process
1.97 3.55e-42 GO:0090304 nucleic acid metabolic process
1.81 4.94e-42 GO:0034641 cellular nitrogen compound metabolic process
1.86 1.23e-41 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.61 1.09e-40 GO:0043170 macromolecule metabolic process
1.51 4.11e-40 GO:0044238 primary metabolic process
1.46 6.32e-40 GO:0008152 metabolic process
1.78 8.66e-40 GO:0006807 nitrogen compound metabolic process
2.90 2.23e-37 GO:0007049 cell cycle
1.82 5.05e-37 GO:0009058 biosynthetic process
1.81 3.13e-35 GO:0044249 cellular biosynthetic process
1.88 2.70e-30 GO:0009059 macromolecule biosynthetic process
3.05 4.79e-30 GO:0022402 cell cycle process
1.88 6.03e-30 GO:0034645 cellular macromolecule biosynthetic process
3.69 4.63e-28 GO:0000279 M phase
3.34 9.68e-28 GO:0022403 cell cycle phase
1.85 1.80e-27 GO:0016070 RNA metabolic process
1.80 6.40e-27 GO:0010467 gene expression
1.80 2.22e-26 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.65 1.13e-25 GO:0060255 regulation of macromolecule metabolic process
4.19 4.84e-25 GO:0000087 M phase of mitotic cell cycle
1.76 1.28e-24 GO:0010556 regulation of macromolecule biosynthetic process
2.08 2.01e-24 GO:0006996 organelle organization
3.50 2.29e-24 GO:0051301 cell division
1.74 3.11e-24 GO:0010468 regulation of gene expression
1.73 4.97e-24 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.61 9.89e-24 GO:0031323 regulation of cellular metabolic process
3.29 1.05e-23 GO:0000278 mitotic cell cycle
1.79 1.20e-23 GO:0051252 regulation of RNA metabolic process
1.71 1.81e-23 GO:0051171 regulation of nitrogen compound metabolic process
4.12 2.04e-23 GO:0000280 nuclear division
4.12 2.04e-23 GO:0007067 mitosis
1.60 2.98e-23 GO:0080090 regulation of primary metabolic process
1.79 3.43e-23 GO:0006355 regulation of transcription, DNA-dependent
1.55 3.43e-23 GO:0019222 regulation of metabolic process
1.70 4.80e-23 GO:0009889 regulation of biosynthetic process
1.71 7.56e-23 GO:0031326 regulation of cellular biosynthetic process
3.96 3.46e-22 GO:0048285 organelle fission
2.83 1.02e-20 GO:0051276 chromosome organization
1.75 2.75e-20 GO:0071841 cellular component organization or biogenesis at cellular level
1.87 3.04e-20 GO:0032774 RNA biosynthetic process
1.63 5.30e-20 GO:0071840 cellular component organization or biogenesis
1.86 1.15e-19 GO:0006351 transcription, DNA-dependent
1.76 2.13e-19 GO:0071842 cellular component organization at cellular level
1.63 3.67e-19 GO:0016043 cellular component organization
2.44 1.01e-17 GO:0033554 cellular response to stress
2.70 1.50e-17 GO:0006259 DNA metabolic process
2.77 2.98e-15 GO:0006974 response to DNA damage stimulus
1.17 1.54e-13 GO:0009987 cellular process
2.70 3.62e-13 GO:0006325 chromatin organization
4.52 1.07e-12 GO:0007059 chromosome segregation
2.92 2.07e-12 GO:0006281 DNA repair
4.31 6.46e-12 GO:0071103 DNA conformation change
2.38 1.08e-10 GO:0051726 regulation of cell cycle
3.53 1.55e-10 GO:0006260 DNA replication
1.55 2.05e-10 GO:0044267 cellular protein metabolic process
3.03 4.09e-10 GO:0010564 regulation of cell cycle process
4.40 1.22e-09 GO:0006323 DNA packaging
1.51 3.00e-08 GO:0048523 negative regulation of cellular process
3.80 4.77e-08 GO:0007126 meiosis
3.80 4.77e-08 GO:0051327 M phase of meiotic cell cycle
3.77 6.34e-08 GO:0051321 meiotic cell cycle
3.76 1.40e-07 GO:0071156 regulation of cell cycle arrest
3.72 1.85e-07 GO:0006310 DNA recombination
2.40 1.99e-07 GO:0016568 chromatin modification
1.82 5.54e-07 GO:0009790 embryo development
3.80 8.68e-07 GO:0000075 cell cycle checkpoint
1.44 9.34e-07 GO:0048519 negative regulation of biological process
1.62 1.18e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.40 1.42e-06 GO:0019538 protein metabolic process
1.42 1.89e-06 GO:0048522 positive regulation of cellular process
1.78 3.31e-06 GO:0010628 positive regulation of gene expression
1.53 3.35e-06 GO:0006950 response to stress
4.55 3.55e-06 GO:0034728 nucleosome organization
1.38 6.01e-06 GO:0048518 positive regulation of biological process
1.50 6.02e-06 GO:0043412 macromolecule modification
1.79 7.41e-06 GO:0051254 positive regulation of RNA metabolic process
1.66 8.01e-06 GO:0009892 negative regulation of metabolic process
1.56 8.83e-06 GO:0009893 positive regulation of metabolic process
5.49 1.33e-05 GO:0000819 sister chromatid segregation
4.25 1.48e-05 GO:0071824 protein-DNA complex subunit organization
1.67 1.48e-05 GO:0010605 negative regulation of macromolecule metabolic process
5.79 1.64e-05 GO:0016126 sterol biosynthetic process
1.72 1.65e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 2.00e-05 GO:0007275 multicellular organismal development
1.67 2.13e-05 GO:0031324 negative regulation of cellular metabolic process
1.56 2.48e-05 GO:0031325 positive regulation of cellular metabolic process
1.33 2.54e-05 GO:0032502 developmental process
1.76 2.59e-05 GO:0045893 positive regulation of transcription, DNA-dependent
4.26 3.30e-05 GO:0065004 protein-DNA complex assembly
1.49 3.32e-05 GO:0006464 protein modification process
1.69 3.60e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.69 3.73e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.94 4.75e-05 GO:0009792 embryo development ending in birth or egg hatching
1.64 8.01e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
4.45 8.18e-05 GO:0006334 nucleosome assembly
1.89 8.27e-05 GO:0006396 RNA processing
4.19 1.03e-04 GO:0031497 chromatin assembly
1.91 1.22e-04 GO:0043009 chordate embryonic development
1.47 1.48e-04 GO:0044281 small molecule metabolic process
1.62 1.60e-04 GO:0044085 cellular component biogenesis
3.92 1.63e-04 GO:0006333 chromatin assembly or disassembly
5.24 2.54e-04 GO:0000070 mitotic sister chromatid segregation
1.76 4.81e-04 GO:0043933 macromolecular complex subunit organization
1.33 4.90e-04 GO:0048856 anatomical structure development
1.72 5.14e-04 GO:0051172 negative regulation of nitrogen compound metabolic process
2.17 5.36e-04 GO:0018193 peptidyl-amino acid modification
1.60 5.75e-04 GO:0031328 positive regulation of cellular biosynthetic process
5.70 6.93e-04 GO:0006695 cholesterol biosynthetic process
2.65 7.51e-04 GO:0051052 regulation of DNA metabolic process
1.58 9.20e-04 GO:0009891 positive regulation of biosynthetic process
1.71 9.45e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.96 1.35e-03 GO:0051053 negative regulation of DNA metabolic process
2.30 1.52e-03 GO:0051186 cofactor metabolic process
1.76 1.66e-03 GO:0065003 macromolecular complex assembly
1.55 1.72e-03 GO:0010941 regulation of cell death
1.60 2.04e-03 GO:0022607 cellular component assembly
6.95 2.73e-03 GO:0045132 meiotic chromosome segregation
3.02 3.27e-03 GO:0034504 protein localization to nucleus
2.34 3.51e-03 GO:0016569 covalent chromatin modification
1.55 3.62e-03 GO:0042981 regulation of apoptosis
2.03 4.00e-03 GO:0001701 in utero embryonic development
3.88 4.08e-03 GO:0031570 DNA integrity checkpoint
4.03 4.99e-03 GO:0006261 DNA-dependent DNA replication
1.65 5.57e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
8.65 6.00e-03 GO:0006270 DNA-dependent DNA replication initiation
1.53 6.45e-03 GO:0043067 regulation of programmed cell death
2.31 6.58e-03 GO:0016570 histone modification
3.13 9.11e-03 GO:0006694 steroid biosynthetic process
1.60 9.49e-03 GO:0009890 negative regulation of biosynthetic process
1.60 1.10e-02 GO:0031327 negative regulation of cellular biosynthetic process
3.05 1.38e-02 GO:0006275 regulation of DNA replication
2.79 1.46e-02 GO:0051188 cofactor biosynthetic process
1.50 1.50e-02 GO:0050793 regulation of developmental process
2.33 1.55e-02 GO:0006732 coenzyme metabolic process
1.60 1.59e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.95 1.77e-02 GO:0034621 cellular macromolecular complex subunit organization
2.47 1.77e-02 GO:0006913 nucleocytoplasmic transport
2.42 1.86e-02 GO:0006457 protein folding
1.30 1.88e-02 GO:0048731 system development
1.89 1.88e-02 GO:0016071 mRNA metabolic process
1.99 1.96e-02 GO:0006397 mRNA processing
5.15 2.21e-02 GO:0031576 G2/M transition checkpoint
2.42 2.70e-02 GO:0051169 nuclear transport
3.57 2.75e-02 GO:0007127 meiosis I
1.61 2.82e-02 GO:0010629 negative regulation of gene expression
4.24 3.01e-02 GO:0008156 negative regulation of DNA replication
1.80 3.01e-02 GO:0032583 regulation of gene-specific transcription
2.40 3.10e-02 GO:0010498 proteasomal protein catabolic process
2.40 3.10e-02 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.35 3.21e-02 GO:0048513 organ development
3.68 3.60e-02 GO:0000077 DNA damage checkpoint
2.79 3.62e-02 GO:0051340 regulation of ligase activity
1.97 3.90e-02 GO:0034622 cellular macromolecular complex assembly
1.83 3.94e-02 GO:0044262 cellular carbohydrate metabolic process
1.84 4.30e-02 GO:0002520 immune system development
1.89 4.60e-02 GO:0030163 protein catabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.44 1.09e-80 GO:0044424 intracellular part
1.88 1.36e-79 GO:0005634 nucleus
1.43 2.44e-79 GO:0005622 intracellular
1.57 6.57e-77 GO:0043231 intracellular membrane-bounded organelle
1.57 9.26e-77 GO:0043227 membrane-bounded organelle
1.51 5.82e-76 GO:0043229 intracellular organelle
1.51 5.97e-76 GO:0043226 organelle
1.75 3.92e-45 GO:0044446 intracellular organelle part
1.74 3.41e-44 GO:0044422 organelle part
2.23 3.50e-41 GO:0044428 nuclear part
2.24 3.18e-39 GO:0070013 intracellular organelle lumen
2.22 4.32e-39 GO:0031974 membrane-enclosed lumen
2.24 4.63e-39 GO:0043233 organelle lumen
2.31 9.21e-37 GO:0031981 nuclear lumen
2.44 1.04e-29 GO:0005654 nucleoplasm
1.67 3.34e-27 GO:0032991 macromolecular complex
1.34 1.56e-26 GO:0005737 cytoplasm
3.15 2.40e-26 GO:0005694 chromosome
3.20 3.24e-25 GO:0044427 chromosomal part
1.67 8.19e-22 GO:0043234 protein complex
1.64 5.77e-17 GO:0043228 non-membrane-bounded organelle
1.64 5.77e-17 GO:0043232 intracellular non-membrane-bounded organelle
3.52 1.43e-15 GO:0000228 nuclear chromosome
3.62 2.04e-14 GO:0044454 nuclear chromosome part
1.12 4.37e-14 GO:0005623 cell
1.12 4.37e-14 GO:0044464 cell part
4.45 1.75e-12 GO:0000793 condensed chromosome
2.24 5.81e-12 GO:0015630 microtubule cytoskeleton
1.31 1.85e-11 GO:0044444 cytoplasmic part
2.05 1.81e-10 GO:0044451 nucleoplasm part
3.00 2.87e-10 GO:0000785 chromatin
3.57 4.48e-10 GO:0000775 chromosome, centromeric region
5.07 9.31e-10 GO:0000794 condensed nuclear chromosome
3.39 3.85e-07 GO:0005819 spindle
3.74 9.01e-07 GO:0000776 kinetochore
1.52 4.86e-06 GO:0005739 mitochondrion
1.52 5.47e-06 GO:0005829 cytosol
4.45 1.30e-05 GO:0030496 midbody
2.41 2.45e-05 GO:0005815 microtubule organizing center
2.47 3.24e-05 GO:0005813 centrosome
3.91 5.78e-05 GO:0034399 nuclear periphery
4.29 5.89e-05 GO:0016363 nuclear matrix
2.12 7.80e-05 GO:0044432 endoplasmic reticulum part
3.33 2.77e-04 GO:0032993 protein-DNA complex
3.53 6.75e-04 GO:0000792 heterochromatin
7.61 7.09e-04 GO:0000780 condensed nuclear chromosome, centromeric region
4.94 7.27e-04 GO:0000779 condensed chromosome, centromeric region
4.22 9.38e-04 GO:0000922 spindle pole
1.59 1.41e-03 GO:0012505 endomembrane system
1.77 1.83e-03 GO:0030529 ribonucleoprotein complex
2.02 1.92e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.41 1.92e-03 GO:0005856 cytoskeleton
2.02 3.18e-03 GO:0005789 endoplasmic reticulum membrane
1.51 3.56e-03 GO:0044430 cytoskeletal part
1.63 3.71e-03 GO:0031967 organelle envelope
1.61 6.38e-03 GO:0031975 envelope
2.68 1.14e-02 GO:0000790 nuclear chromatin
3.14 2.27e-02 GO:0034708 methyltransferase complex
3.14 2.27e-02 GO:0035097 histone methyltransferase complex
5.20 2.67e-02 GO:0045120 pronucleus
3.28 4.43e-02 GO:0000786 nucleosome

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.82 5.27e-30 GO:0003676 nucleic acid binding
1.26 8.42e-27 GO:0005488 binding
1.93 1.77e-24 GO:0003677 DNA binding
1.99 8.49e-13 GO:0030528 transcription regulator activity
1.53 5.04e-10 GO:0000166 nucleotide binding
1.29 1.08e-08 GO:0003824 catalytic activity
1.63 1.38e-08 GO:0005524 ATP binding
1.60 3.47e-08 GO:0032559 adenyl ribonucleotide binding
1.60 5.25e-08 GO:0030554 adenyl nucleotide binding
1.24 4.71e-07 GO:0005515 protein binding
1.79 1.57e-06 GO:0001071 nucleic acid binding transcription factor activity
1.79 1.57e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.48 2.91e-06 GO:0035639 purine ribonucleoside triphosphate binding
2.61 4.29e-06 GO:0043566 structure-specific DNA binding
1.46 8.88e-06 GO:0032555 purine ribonucleotide binding
1.46 9.30e-06 GO:0032553 ribonucleotide binding
1.45 1.22e-05 GO:0017076 purine nucleotide binding
3.63 4.07e-05 GO:0042393 histone binding
1.73 5.23e-05 GO:0003723 RNA binding
2.10 5.64e-05 GO:0016563 transcription activator activity
1.74 1.18e-04 GO:0043565 sequence-specific DNA binding
1.62 2.09e-04 GO:0019899 enzyme binding
7.42 2.94e-04 GO:0000217 DNA secondary structure binding
1.41 4.34e-04 GO:0016740 transferase activity
2.31 5.62e-04 GO:0003682 chromatin binding
2.07 3.21e-03 GO:0019901 protein kinase binding
3.71 3.68e-03 GO:0003697 single-stranded DNA binding
3.71 3.68e-03 GO:0043021 ribonucleoprotein binding
1.92 5.78e-03 GO:0008134 transcription factor binding
10.30 1.22e-02 GO:0000400 four-way junction DNA binding
2.37 1.34e-02 GO:0003690 double-stranded DNA binding
1.86 1.74e-02 GO:0016564 transcription repressor activity
2.43 2.40e-02 GO:0016853 isomerase activity
4.41 2.50e-02 GO:0003678 DNA helicase activity
1.57 3.86e-02 GO:0017111 nucleoside-triphosphatase activity
8.83 3.99e-02 GO:0004576 oligosaccharyl transferase activity
8.83 3.99e-02 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity
1.21 4.34e-02 GO:0043169 cation binding